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Anti-CRYAB Antibody BHA11300872
Alternative: Alpha-crystallin B chain|Alpha(B)-crystallin|Heat shock protein beta-5|HspB5|Renal carcinoma antigen NY-REN-27|Rosenthal fiber component|CRYAB|CRYA2|αB-Crystallin
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 11q23.1
Immunogen: Synthetic peptide, corresponding to amino acids 11-60 of Human Crystallin-αB.
Description: α-crystallins consist of three gene products, αA, αB and αC-crystallin, which are members of the small heat shock protein family (HSP 20). They are induced by heat shock, and act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, α-crystallins do not renature these proteins. Expression of αA-crystallin is restricted to the lens. Defects in this gene cause autosomal dominant congenital cataracts (ADCC). The human αB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of αB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.
TARGETWeight: 26 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Crystallin-αB (S41) polyclonal antibody detects endogenous levels of Crystallin-αB protein.
Description: Immunohistochemistry (IHC) analyzes of Crystallin-αB (S41) pAb in paraffin-embedded human colorectal cancer carcinoma tissue at 1:100.