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Anti-SHC1 Antibody BHA11300848
Alternative: SHC-transforming protein 1|SHC-transforming protein 3|SHC-transforming protein A|Src homology 2 domain-containing-transforming protein C1|SH2 domain protein C1|SHC1|SHC|SHCA
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 1q21.3
Immunogen: Synthetic peptide, corresponding to amino acids 310-360 of Human Shc.
Description: Critical components of this process include adapter proteins such as Shc and IRS-1 that lack detectable catalytic activity. These are immediate substrates of receptor tyrosine kinase activity and serve to physically link activated receptors to downstream signaling components. Whereas Shc has been implicated in signaling by diverse receptor families, IRS-1 serves primarily as the major insulin receptor substrate. Shc also participates in insulin signaling by linking the insulin receptor to Ras by forming complexes with the adapter protein GRB2 and Sos independently of IRS-1. A protein immunologically related to IRS-1, originally designated 4PS and now known as IRS-2, was shown to become highly tyrosine phosphorylated in response to IL-4 or IGF-1 in cells lacking IRS-1. An additional member of this family of signaling intermediates, Shb, is a SH2-containing protein with characteristic proline-rich domains.
TARGETWeight: 46,52,66 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Shc (E343) polyclonal antibody detects endogenous levels of Shc protein.
Description: Immunohistochemistry (IHC) analyzes of Shc (E343) pAb in paraffin-embedded human breast carcinoma tissue.