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Anti-ERBB3 Antibody BHA11300804
Alternative: ERBB3|ERBB3 protein|erbB3 S|ERBB3|Glial growth factor receptor|HER-3|HER3|LCCS2|MDA BF 1|MGC88033|p180 ErbB3|p45 sErbB3|p85 sErbB3|proto-oncogene-like protein c ErbB 3
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 12q13.2
Immunogen: Synthetic peptide, corresponding to amino acids 1250-1300 of Human ErbB-3.
Description: The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.
TARGETWeight: 148, 185 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: ErbB-3 (S1285) polyclonal antibody detects endogenous levels of ErbB-3 protein.
Description: Western blot (WB) analysis of ErbB-3 (S1285) polyclonal antibody at 1:500 dilutionLane1:MCF-7 cell lysateLane2:Mouse brain tissue lysateLane3:H9C2 cell lysate
Description: Immunohistochemistry (IHC) analyzes of ErbB-3 (S1285) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.