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Anti-TSC2 Antibody BHA11300758
Alternative: Tuberin|Tuberous sclerosis 2 protein|TSC2|TSC4
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 16p13.3
Immunogen: Synthetic peptide, corresponding to amino acids 900-950 of Human Tuberin.
Description: Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.
TARGETWeight: 200 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Tuberin/TSC2 (F933) polyclonal antibody detects endogenous levels of Tuberin/TSC2 protein.
Description: Western blot (WB) analysis of Tuberin (F933) polyclonal antibody at 1:500 dilutionLane1:C6 whole cell lysate(40ug)Lane2:MEF whole cell lysate(40ug)Lane3:A549 whole cell lysate(40ug)Lane4:L02 whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of Tuberin (F933) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Description: Western blot (WB) analysis of Tuberin (F933) pAb at 1:500 dilutionLane1:A549 whole cell lysate(40ug)Lane2:L02 whole cell lysate(40ug)Lane3:HEK293T whole cell lysate(40ug)Lane4:PANC-1 whole cell lysate(40ug)Lane5:The Brain tissue lysate of Rat(40ug)Lane6:The Brain tissue lysate of Mouse(40ug)Lane7:NIH-3T3 whole cell lysate(40ug)