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Anti-INPP5D Antibody BHA11300749
Alternative: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1|Inositol polyphosphate-5-phosphatase of 145 kDa|SIP-145|SH2 domain-containing inositol 5'-phosphatase 1|SH2 domain-containing inositol phosphatase 1|SHIP-1|p150Ship|hp51CN|INPP5D|SHIP|SHIP1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 2q37.1
Immunogen: Synthetic peptide, corresponding to amino acids 980-1030 of Human SHIP1.
Description: The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a 170 kDa glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino terminal SH2 domain, a proline-rich region, and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1, 3, 4, 5 -tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways
TARGETWeight: 133 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: SHIP1 (M1014) polyclonal antibody detects endogenous levels of SHIP1 protein.
Description: Western blot (WB) analysis of SHIP1 (M1014) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate(40ug)Lane2:SK-OVCAR3 whole cell lysate(40ug)