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Anti-RPS6KA5 Antibody BHA11300710
Alternative: Ribosomal protein S6 kinase alpha-5|S6K-alpha-5|90 kDa ribosomal protein S6 kinase 5|Nuclear mitogen- and stress-activated protein kinase 1|RSK-like protein kinase|RSKL|RPS6KA5|MSK1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 14q32.11
Immunogen: Synthetic peptide, corresponding to amino acids 331-380 of Human MSK1.
Description: MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.
TARGETWeight: 90 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: MSK1 (M355) polyclonal antibody detects endogenous levels of MSK1 protein.
Description: Western blot (WB) analysis of MSK1 (M355) polyclonal antibody at 1:500 dilutionLane1:H9C2 whole cell lysate(40ug)Lane2:The Brain tissue lysate of Mouse(40ug)Lane3:MCF-7 whole cell lysate(40ug)Lane4:A549 whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of MSK1 (M355) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Description: Western blot (WB) analysis of MSK1 (M355) pAb at 1:500 dilutionLane1:COS-7 whole cell lysate(40ug)Lane2:C6 whole cell lysate(40ug)Lane3:MEF whole cell lysate(40ug)Lane4:HEK293T whole cell lysate(40ug)