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Anti-MAP2K1 Antibody BHA11300706
Alternative: Dual specificity mitogen-activated protein kinase kinase 1|MAP kinase kinase 1|MAPKK 1|MKK1|ERK activator kinase 1|MAPK/ERK kinase 1|MEK 1|MAP2K1|MEK-1|PRKMK1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 15q22.31
Immunogen: Synthetic peptide, corresponding to amino acids 260-310 of Human MEK1.
Description: MEK1 (Mitogen activated protein kinase kinase 1) catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. MEK1 activates ERK1 and ERK2 MAP kinases. Mitogen activated protein kinase kinase 2 (MEK2 or MAPKK2) is a member of a family of tyrosine/threonine protein kinases that activate the ERK1 and 2 and MAPK enzymes by phosphorylating both residues within the threonine/glutamate/tyrosine (TEY) motif in the activation loop. MEK1 and 2 are also activated by dual phosphorylation, which occurs on serine 218 and 222, in the activation loop of the MEK. Threonine 292 of MEK1 is phosphorylated by ERK 2, which serves as a negative feedback loop by suppressing activation of MEK1.
TARGETWeight: 43 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: MEK1 (G281) polyclonal antibody detects endogenous levels of MEK1 protein.
Description: Western blot (WB) analysis of MEK1 (G281) polyclonal antibody at 1:500 dilutionLane1:MEF whole cell lysate(40ug)Lane2:PC12 whole cell lysate(40ug)Lane3:HepG2 whole cell lysate(40ug)Lane4:HEK293T whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of MEK1 (G281) pAb in paraffin-embedded human breast carcinoma tissue.