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Anti-LAT (D199) Antibody BHA11300703
Antigen: LAT (D199)
Alternative: Linker for activation of T-cells family member 1|36 kDa phospho-tyrosine adapter protein|pp36|p36-38|LAT
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Immunogen: Synthetic peptide, corresponding to amino acids 171-220 of Human LAT.
Description: LAT, a transmembrane adaptor protein expressed in T, NK and mast cells, is an important mediator for T cell receptor (TCR) signaling. Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets. The phosphorylation of LAT at Tyr171 and 191 enables the binding of Grb2, Gads/SLP-76, PLCgamma1 and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways.
TARGETWeight: 38 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: LAT (D199) polyclonal antibody detects endogenous levels of LAT protein
Description: Western blot (WB) analysis of LAT (D199) pAb at 1:500 dilutionLane1:The Spleen tissue lysate of Mouse(40ug)Lane2:THP-1 whole cell lysate(40ug)Lane3:HEK293TK562 whole cell lysate(40ug)