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Anti-ESR1 Antibody BHA11300692
Alternative: Estrogen receptor|ER-alpha|ER|ESR1|ESR|NR3A1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 6q25.1-q25.2
Immunogen: Synthetic peptide, corresponding to amino acids 501-550 of Human ERα.
Description: Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor uperfamily of ligand-activated transcription factors. Estrogen receptors, ncluding ERα and ERβ, contain DNA binding and ligand binding domains nd are critically involved in regulating the normal function of reproductive issues. ERα and ERβ have been shown to be differentially activated by various igands. Receptor-ligand interactions trigger a cascade of events, including issociation from heat shock proteins, receptor dimerization, phosphorylation nd the association of the hormone activated receptor with specific regulatory lements in target genes. Evidence suggests that ERα and ERβ may be egulated by distinct mechanisms even though they share many functional characteristics.
TARGETWeight: 66 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: ER-α (K531) polyclonal antibody detects endogenous levels of ER-α protein.
Description: Immunohistochemistry (IHC) analyzes of ERα (K531) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.