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Anti-CBL Antibody BHA11300677
Alternative: E3 ubiquitin-protein ligase CBL|Casitas B-lineage lymphoma proto-oncogene|Proto-oncogene c-Cbl|RING finger protein 55|Signal transduction protein CBL|CBL|CBL2|RNF55
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Immunogen: Synthetic peptide, corresponding to amino acids 665-710 of Human Cbl.
Description: Cbl (also designated the c-Cbl proto-oncogene, E3 ubiquitin-protein ligase CBL ,Casitas B-lineage lymphoma proto-oncogene and RING finger protein 55) has been identified as the cellular homolog of the v-Cbl oncogene isolated from an NFS/N mouse that developed a pre-B cell lymphoma following infection with the replication-competent Cas Br-M murine leukemic virus. c-Cbl is expressed at relatively high levels in a wide range of hematopoietic tumor cell lines as well as in normal tissues such as thymus and testis. The c-Cbl gene product has been identified as a cytoplasmic protein with apparent DNA binding and dimerization domains characteristic of transcription factors. A single c-Cbl locus termed CBL2 has been mapped to human chromosome 11q23. This region of chromosome 11 is involved in translocations and deletions in a broad range of leukemias; c-Cbl has been found to be translocated from chromosome 11 in leukemias with either t(4;11) or t(11;14) abnormalities.
TARGETWeight: 100, 120kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: CBL (G694) polyclonal antibody detects endogenous levels of CBL protein.
Description: Western blot (WB) analysis of Cbl(G694) polyclonal antibody at 1:500 dilutionLane1:786-O whole cell lysate(40ug)Lane2:SK-OVCAR3 whole cell lysate(40ug)Lane3:MCF-7 whole cell lysate(40ug)Lane4:The Testis tissue lysate of Mouse(40ug)Lane5:The Testis tissue lysate of Rat(40ug)
Description: Immunohistochemistry (IHC) analyzes of Cbl (G694) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.