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Anti-ARRB1 Antibody BHA11300667
Alternative: ARB 1|ARB1|ARR 1|ARR1|ARRB 1|ARRB1|Arrestin 2|Arrestin beta 1|Arrestin beta-1|Beta-arrestin-1|Arrestin-β1|Arrestin β1|β-arrestin-1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 11q13.4
Immunogen: Synthetic peptide, corresponding to amino acids 390-440 of Human Arrestin-β-1.
Description: Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane.
TARGETWeight: 50 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Arrestin-β-1 (E406) polyclonal antibody detects endogenous levels of Arrestin-β-1 protein.
Description: Immunohistochemistry (IHC) analyzes of Arrestin-β-1 (E406) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.