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Anti-AKT1S1 Antibody BHA11300663
Alternative: Proline-rich AKT1 substrate 1|40 kDa proline-rich AKT substrate|AKT1S1|PRAS40
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 19q13.33
Immunogen: Synthetic peptide, corresponding to amino acids 210-260 of Human PRAS40.
Description: Akt, also known as protein kinase B, is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway. This protein kinase has been implicated in insulin signaling, stimulation of cellular growth, inhibition of apoptosis and transformation of cells. The proline-rich Akt substrate PRAS40, also designated AKT1S1, becomes phosphorylated by activated Akt on Ser or Thr residues in the motif RXRXX(S/T). Phosphorylated PRAS40 subsequently binds 14-3-3 in a sequence-specific manner, thereby inducing such changes as alteration of protein subcellular localization and regulation of intrinsic enzymatic activity. Studies also suggest that PRAS40 phosphorylation and its interaction with pAkt and 14-3-3 may play an important role in neuroprotection mediated by NGF in apoptotic neuronal cell death after cerebral ischemia. PRAS40 maps to human chromosome 19q13.33.
TARGETWeight: 40 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Akt1 S1 (P240) polyclonal antibody detects endogenous levels of Akt1 S1 protein.
Description: Western blot (WB) analysis of PRAS40 (P240) polyclonal antibody at 1:500 dilution Lane1:H9C2 whole cell lysate(40ug)Lane2:L02 whole cell lysate(40ug)Lane3:MEF whole cell lysate(40ug)Lane4:A549 whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of Akt1 S1 (P240) pAb in paraffin-embedded human breast tissue.