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Anti-XRCC1 Antibody BHA11300655
Alternative: XRCC1|X-ray repair cross-complementing protein 1|XRCC1|XRCC1. XRCC 1. XRCC-1. X-ray cross complementing factor X ray. DNA ligase. complementation protein
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 19q13.2
Immunogen: Synthetic peptide, corresponding to amino acids 520-570 of Human XRCC1.
Description: The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a 70 kDa protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination.
TARGETWeight: 80 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: XRCC1 (G552) polyclonal antibody detects endogenous levels of XRCC1 protein.
Description: Western blot (WB) analysis of XRCC1 (G552) polyclonal antibody at 1:500 dilutionLane1:HepG2 whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate
Description: Immunohistochemistry (IHC) analyzes of XRCC1 (G552) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.
Description: Western blot (WB) analysis of XRCC1 (G552) pAb at 1:500 dilutionLane1:SK-OVCAR3 whole cell lysate(40ug)Lane2:Hela whole cell lysate(40ug)Lane3:HEK293T whole cell lysate(40ug)Lane4:PC12 whole cell lysate(40ug)Lane5:BV2 whole cell lysate(40ug)