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Anti-PIAS1 Antibody BHA11300625
Alternative: E3 SUMO-protein ligase PIAS1|Protein inhibitor of activated STAT protein 1|Gu binding protein|GBP|RNA helicase II binding protein|DEAD/H box-binding protein 1|DDXBP1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 15q23
Immunogen: Synthetic peptide, corresponding to amino acids 1-50 of Human PIAS 1.
Description: The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.
TARGETWeight: 72 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: PIAS1 (G24) polyclonal antibody detects endogenous levels of PIAS1 protein.
Description: Western blot (WB) analysis of PIAS 1 (G24) polyclonal antibody at 1:500 dilutionLane1:MCF-7 whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate
Description: Immunohistochemistry (IHC) analyzes of PIAS 1 (G24) pAb in paraffin-embedded human lung carcinoma tissue at 1:100.
Description: Western blot (WB) analysis of PIAS 1 (G24) pAb at 1:500 dilutionLane1:SGC7901 whole cell lysate(40ug)Lane2:A549 whole cell lysate(40ug)Lane3:CT26 whole cell lysate of Rat(40ug)Lane4:The Testis tissue lysate of Rat(40ug)