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Anti-IKBKB Antibody BHA11300568
Alternative: Inhibitor of nuclear factor kappa B kinase beta subunit|I-kappa-B-kinase beta|IkBKB|IKK-B|I-kappa-B kinase 2|IKK2|Nuclear factor NF-kappa-B inhibitor kinase beta|NFKBIKB
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 8p11.21
Immunogen: Synthetic peptide, corresponding to amino acids 161-210 of Human IKKβ.
Description: The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylate on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on Serines 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFκB activation in response to proinflammatory cytokines. Phosphorylation of IκB by IKKα is stimulated by the NFκB inducing kinase (NIK), which itself is a central regulato for NFκB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation.
TARGETWeight: 86 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: IKK-β (F182) polyclonal antibody detects endogenous levels of IKK-β protein.
Description: Immunohistochemistry (IHC) analyzes of IKK-β (F182) pAb in paraffin-embedded human breast carcinoma tissue.