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Anti-GSK3B Antibody BHA11300563
Alternative: Glycogen Synthase Kinase 3 Beta|Glycogen synthase kinase-3 beta|GSK 3 beta|GSK-3 beta|GSK3B|GSK3B|GSK3beta isoform|Serine/threonine-protein kinase GSK3B
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 3q13.33
Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of Human GSK3β.
Description: Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer’s disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer’s disease.
TARGETWeight: 46 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: GSK3β (S2) polyclonal antibody detects endogenous levels of GSK3β protein.
Description: Western blot (WB) analysis of GSK3β (S2) polyclonal antibody at 1:500 dilutionLane1:H9C2 whole cell lysate(40ug)Lane2:CT26 whole cell lysate(40ug)Lane3:COS-7 whole cell lysate(40ug)Lane4:L02 whole cell lysate(40ug)Lane5:HEK293T whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of GSK3β (S2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.