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Anti-E2F1 Antibody BHA11300558
Alternative: Transcription factor E2F1|E2F-1|PBR3|Retinoblastoma-associated protein 1|RBAP-1|Retinoblastoma-binding protein 3|RBBP-3|pRB-binding protein E2F-1|E2F1|RBBP3
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 20q11.22
Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human E2F-1.
Description: The E2F transcription factors are essential for regulation of the cell cycle. Physiological E2F is a heterodimer composed of an E2F subunit together with a DP subunit. Six members of the E2F family have been identified, and each E2F subunit has a DNA binding and a dimerization domain. E2F-1 to -5 activate transcription. E2F-1 to -3 bind pRb, and E2F-4 and -5 bind p107 or p130, and these interactions are under cell cycle control. E2F-1 has oncogenic properties in vivo and in vitro. E2F-1 can induce apoptosis through p53-dependent and -independent mechanisms. E2F-1 is stress-responsive, and is regulated by a PI3-kinase-like kinase family such as the ATM/ATR kinases.
TARGETWeight: 47 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: E2F1 (D426) polyclonal antibody detects endogenous levels of E2F1 protein.
Description: Immunohistochemistry (IHC) analyzes of E2F-1 (D426) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.