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Anti-STAT6 Antibody BHA11300504
Alternative: Signal transducer and activator of transcription 6|IL-4 Stat|STAT6
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 12q13
Immunogen: Synthetic peptide, corresponding to amino acids 610-660 of Human Stat6.
Description: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of JAK kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expresion of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by Prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
TARGETWeight: 94 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: STAT6 (R639) polyclonal antibody detects endogenous levels of STAT6 protein.
Description: Western blot (WB) analysis of Stat6 (R639) pAb at 1:500 dilutionLane1:SGC7901 whole cell lysate(40ug)Lane2:SK-OVCAR3 whole cell lysate(40ug)Lane3:CT26 whole cell lysate(40ug)Lane4:PC12 whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of Stat6 (R639) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.