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Home / Primary Antibodies / IHC Antibodies

Anti-SCN11A/SCN10A/SCN9A/SCN8A/SCN5A/SCN4A/SCN3A/SCN2A/SCN1A Antibody BHA11300491

SKU : BHA11300491

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Mfr.No.	BS1328
Alternative Names	SCN2A ; NAC2, SCN2A1, SCN2A2 ; Nav1.1 ; NAC1 ; SCN1 ; SCN1A ; Nav1.2 ; SCN3A ; KIAA1356, NAC3 ; Nav1.3 ; Nav1.4 ; SCN4A ; Nav1.5 ; SCN5A ; Nav1.6 ; SCN8A ; MED ; Nav1.7 ; SCN9A ; NENA ; Nav1.8 ; SCN10A ; Nav1.9 ; hNaN ; SCN11A ; SCN12A ; SNS2
Antigen	SCN11A/SCN10A/SCN9A/SCN8A/SCN5A/SCN4A/SCN3A/SCN2A/SCN1A
Categories	Primary Antibodies
Clonality	polyclonal
Description	Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddel’s syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 1470-1520 of Human SCN5A.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P35498/Q99250/Q9NY46/P35499/Q14524/Q9UQD0/Q15858/Q9Y5Y9/Q9UI33
Uniprot	P35498/Q99250/Q9NY46/P35499/Q14524/Q9UQD0/Q15858/Q9Y5Y9/Q9UI33
Weight	230 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: Sodium Channel-pan (K1493) polyclonal antibody detects endogenous levels of Sodium Channel-pan protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

IHC, IF

Description

IHC ; IF

Dilution

IHC	1:50-1:200
IF	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11300491	BS1328	50µl	$190.44		Add to Cart
BHA11300491	BS1328	100µl	$294.44		Add to Cart

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