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Anti-PTEN Antibody BHA11300467
Alternative: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|Mutated in multiple advanced cancers 1|Phosphatase and tensin homolog|PTEN|MMAC1|TEP1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 10q23.31
Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human PTEN.
Description: As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm, and it shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.
TARGETWeight: 47, 54 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: PTEN (S364) polyclonal antibody detects endogenous levels of PTEN protein.
Description: Western blot (WB) analysis of PTEN (S364) polyclonal antibody at 1:500 dilutionLane1:HEK293T cell lysateLane2:Mouse spleen tissue lysateLane3:Rat spleen tissue lysate
Description: Immunohistochemistry (IHC) analyzes of PTEN (S364) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Description: Western blot (WB) analysis of PTEN (S364) pAb at 1:500 dilutionLane1:L02 whole cell lysate(40ug)Lane2:MCF-7 whole cell lysate(40ug)Lane3:The Brain tissue lysate of Mouse(40ug)Lane4:The Brain tissue lysate of Rat(40ug)
Description: Western blot (WB) analysis of PTEN (S364) pAb at 1:500 dilutionLane1:PC12 whole cell lysate(40ug)Lane2:The kidney tissue lysate of Mouse(40ug)Lane3:The kidney tissue lysate of Rat(40ug)Lane4:The lung tissue lysate of Mouse(40ug)Lane5:The lung tissue lysate of Rat(40ug)