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Anti-JAK1 Antibody BHA11300363
Alternative: Tyrosine-protein kinase JAK1|Janus kinase 1|JAK-1|JAK1A
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 1p31.3
Immunogen: Synthetic peptide, corresponding to amino acids 980-1030 of Human JAK1.
Description: JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
TARGETWeight: 132 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: JAK1 (I1016) polyclonal antibody detects endogenous levels of JAK1 protein.
Description: Western blot (WB) analysis of JAK1 (I1016) polyclonal antibody at 1:500 dilutionLane1:DLD whole cell lysate(40ug)Lane2:U87MG whole cell lysate(40ug)Lane3:The Brain tissue lysate of Mouse(40ug)Lane4:The Brain tissue lysate of Rat(40ug)
Description: Immunohistochemistry (IHC) analyzes of JAK1 (I1016) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.