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Anti-HDAC1 Antibody BHA11300334
Alternative: Histone deacetylase 1|HD1|RPD3L1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 1p35.2-p35.1
Immunogen: Synthetic peptide, corresponding to amino acids 435-486 of Human HDAC1.
Description: Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
TARGETWeight: 55 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: HDAC1(E468) polyclonal antibody detects endogenous levels of HDAC1 protein.
Description: Western blot (WB) analysis of HDAC1 (E468) polyclonal antibody at 1:500 dillutionLane1:HEK293T whole cell lysate(40μg)Lane2:Hela whole cell lysate(40μg)Lane3:The Kidney tissue lysate of Mouse(40μg)Lane4:The Kidney tissue lysate of Rat(40μg)Lane5:The Heart tissue lysate of Mouse(40μg)Lane6:The Heart tissue lysate of Rat(40μg)
Description: Immunohistochemistry (IHC) analyzes of HDAC1 (E468) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Description: Immunoprecipitation of L02 cell lysate using HDAC1 (E468) pAb (Sepharose Bead Conjugate) #BD0048(lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate)#BD0048 (lane 4 and lane 5) .Lane 1 is 30% input. The western blot was probed using HDAC1 (E468) pAb #BS1160.“↑”（supernatant）; “↓”（deposition）