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Anti-GABBR1 Antibody BHA11300309
Alternative: Gamma-aminobutyric acid type B receptor subunit 1|GABA-B receptor 1|GABA-B-R1|GABA-BR1|GABABR1|Gb1|GABBR1|GPRC3A|GABB-R1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 6p22.1
Immunogen: Synthetic peptide, corresponding to amino acids 870-913 of Human GABAB R1.
Description: The GABAB R receptor is a heterodimer that consists of two multi-pass membrane proteins, designated GABAB R1 and GABAB R2, both of which belong to the G protein-coupled receptor family and are highly expressed in brain tissue. Together, GABAB R1 and GABAB R2 play a crucial role in the fine-tuning of inhibitory synaptic transmissions and are implicated in slow wave sleep, muscle relaxation, hippocampal long-term potentiation and antinociception events. Both GABAB R1 and GABAB R2 are regulated by G proteins that have a variety of functions, including activation of potassium channels, inhibition of adenylyl cyclase (A cyclase) activity and modulation of inositol phospholipid hydrolysis.
TARGETWeight: 110 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: GABAB R1 (I902) polyclonal antibody detects endogenous levels of GABA-B Receptor protein.
Description: Immunohistochemistry (IHC) analyzes of GABAB R1 (I902) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.