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Anti-FOS Antibody BHA11300306
Alternative: Proto-oncogene c-Fos|Cellular oncogene fos|G0/G1 switch regulatory protein 7|FOS|G0S7
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 14q24.3
Immunogen: Synthetic peptide, corresponding to amino acids 1-50 of Human c-Fos.
Description: The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites. Human c-Fos may be phosphorylated at Thr 232.
TARGETWeight: 62 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Fos (F3) polyclonal antibody detects endogenous levels of Fos protein.
Description: Western blot (WB) analysis of c-Fos (F3) polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysate(40ug)Lane2:HEK293T whole cell lysate(40ug)Lane3:SK-OVCAR3 whole cell lysate(40ug)
Description: Immunohistochemistry (IHC) analyzes of c-Fos (F3) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.