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Anti-BCL2L11 Antibody BHA11300222
Alternative: Bcl-2-like protein 11|Bcl2-L-11|Bcl2-interacting mediator of cell death|BCL2L11|BIM
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 2q13
Immunogen: Synthetic peptide, corresponding to amino acids 1-50 of Human Bim.
Description: Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS or BimL, implying a unique role for BimEL in cell survival signaling.
TARGETWeight: 25 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: Bim (A2) polyclonal antibody detects endogenous levels of Bim protein.
Description: Immunohistochemistry (IHC) analyzes of Bim (A2) pAb in paraffin-embeddedhuman colon carcinoma tissue at 1:50.showing cell membranes and cytoplasmic staining. Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
Description: Western blot (WB) analysis of Bim (A2) pAb at 1:500 dilutionLane1:The Kidney tissue lysate of Rat(41ug)Lane2:The Kidney tissue lysate of Mouse(38ug)Lane3:Hela whole cell lysate(40ug)