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Anti-SMYD3 Antibody BHA11300168
Alternative: Histone-lysine N-methyltransferase SMYD3|SET and MYND domain-containing protein 3|Zinc finger MYND domain-containing protein 1|SMYD3|ZMYND1, ZNFN3A1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 1q44
Immunogen: Recombinant fragment corresponding to a region within C-term amino acids of Human SMYD3.
Description: SET and MYND domain-containing 3 (SMYD3), a 428 amino acid protein, is a member of an RNA polymerase complex and plays a role in transcriptional regulation. SMYD3 methylates Lys 4 of histone H3, a specific tag for epigenetic transcriptional activation. The SMYD3 protein contains an N-terminal MYND-type zinc finger domain, followed by a SET domain, which shows methyltransferase activity. The presence of the heat-shock protein HSP 90α greatly enhances the methyltransferase activity of SMYD3. SMYD3 is expressed in testis and skeletal muscles and is overexpressed in a majority of colorectal carcinomas (CRCs), hepatocellular carcinomas (HCCs) and breast carcinomas (BCs). Inhibition of SMYD3 is a potential chemotherapeutic strategy.
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: SMYD3 polyclonal antibody detects endogenous levels of SMYD3 protein.