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Anti-WDR1 Antibody BHA11300161
Alternative: WD repeat-containing protein 1|Actin-interacting protein 1|AIP1|NORI-1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 4p16.1
Immunogen: Recombinant full length Human WDR1.
Description: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids, which commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms involving signal transduction, apoptosis, transcriptional regulation, cell cycle control. WD repeats serve as sites for protein-protein interaction and some seem to mediate the assembly of protein complexes. With 11 WD repeats, WDR1 (WD repeat domain 1), also known as AIP1 or NORI-1, is a 606 amino acid protein that localizes to the cytoskeleton and is a member of the WD repeat AIP1 family. Existing as two alternatively spliced isoforms, WDR1 induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins.
TARGETWeight: 66 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.Specificity: WDR1 polyclonal antibody detects endogenous levels of WDR1 protein.
Description: Immunohistochemistry (IHC) analyzes of WDR1 pAb in paraffin-embedded human lung carcinoma tissue at 1:50,showing cytoplasm staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.
Description: Immunohistochemistry (IHC) analyzes of WDR1 pAb in paraffin-embedded human rectum carcinoma tissue at 1:50,showing cytoplasm staining.Negative control (the right)Using PBS instead of primary antibody, secondary antibody is Goat Anti-Rabbit IgG-biotin followed by avidin-peroxidase.