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Anti-OLIG2 Antibody BHA11300117
Alternative: Oligodendrocyte transcription factor 2|Oligo2|Class B basic helix-loop-helix protein 1|bHLHb1|Class E basic helix-loop-helix protein 19|bHLHe19|Protein kinase C-binding protein 2|Protein kinase C-binding protein RACK17|OLIG2|BHLHB1|BHLHE19|PRKCBP2|RACK17
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: 21q22.11
Immunogen: Synthetic phosphopeptide derived from human OLIG2 around the phosphorylation site of Serine 147.
Description: OLIG1 and OLIG2 are specifically expressed in nervous tissue as gene regulators of oligodendrogenesis. OLIG2 is more widely expressed in embryonic brain than OLIG1, while OLIG3 is primarily expressed in non-neural tissues. OLIG1 and OLIG2 interact with the Nkx-2.2 homeodomain protein, which is responsible for directing ventral neuronal patterning in response to graded Sonic hedgehog signaling in the embryonic neural tube. These interactions between OLIG proteins and Nkx-2.2 appear to promote the formation of alternate cell types by inhibiting V3 interneuron development. OLIG1 and OLIG2 are abundantly expressed in oligodendroglioma and nearly absent in astrocytomas.
TARGETWeight: 32 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 101% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: p-OLIG2 (S147) polyclonal antibody detects endogenous levels of OLIG2 protein only when phosphorylated at Ser147.
Description: Western blot (WB) analysis of p-olig2(S147) polyclonal antibody at 1:500 dilutionLane1:HepG2 cell lysate treated with EGFLane2:Raw264.7 cell lysate treated with EGFLane3:sp20 cell lysate treated with EGF