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Anti-CDKN1A Antibody BHA11300114
Alternative: Cyclin-dependent kinase inhibitor 1|CDK-interacting protein 1|Melanoma differentiation-associated protein 6|MDA-6|CDKN1A|CAP20|CDKN1|CIP1|MDA6|PIC1|SDI1|WAF1
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: primary antibodies|polyclonal antibodies
Chromosome Location: 6p21.2
Immunogen: Recombinant full length Human P21.
Description: It is now well established that cyclins play a positive role in promoting cell cycle transitions via their ability to associate with and activate their cognate cyclin-dependent kinases (Cdks). Cdk2 associates with cyclins A, D and E, and has been implicated in the control of the G1 to S phase transition in mammals. A novel Cdk-interacting protein, designated p21, Cip1 or WAF1, has been identified in cyclin A, cyclin D1, cyclin E and Cdk2 immunoprecipitates. p21 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk 2, cyclin E-Cdk2, cyclin D1-Cdk4 and cyclin D2-Cdk4 complexes. Expression of p21 is inducible by wildtype, but not mutant, p53. The mouse homolog of p21 is designated CAP20.
TARGETWeight: 21 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.Specificity: P21 (WQ1) polyclonal antibody detects endogenous levels of P21 protein.
Description: Western blot (WB) analysis of P21 (WQ1) polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:Raw264.7 whole cell lysateLane3:H9C2 whole cell lysate
Description: Immunohistochemistry (IHC) analyzes of P21 (WQ1) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.