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Anti-IKBKG Antibody BHA11300105
Alternative: NF-kappa-B essential modulator|NEMO|FIP-3|IkB kinase-associated protein 1|IKKAP1|Inhibitor of nuclear factor kappa-B kinase subunit gamma|I-kappa-B kinase subunit gamma|IKK-gamma|IKKG|IkB kinase subunit gamma|NF-kappa-B essential modifier|IKBKG|FIP3|NEMO|IKK-γ
Species: Homo Sapiens (Human)
Delivery: Free shipping. Usually ships in 7 to 10 business days
Categories: Primary Antibodies|Polyclonal Antibodies
Chromosome Location: Xq28
Immunogen: Synthetic peptide, corresponding to the N-terminual of Human IKKγ.
Description: Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase α (IKKα), previously designated CHUK, interacts with IkB-α and specifically phosphorylates I˚Bα on Serine 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKα is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.
TARGETWeight: 48 kDa
PROPERTYStorage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Desc: Product: 1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.Specificity: IKK-GAMMA(S31) polyclonal antibody detects endogenous levels of IKK-GAMMA protein.
Description: Western blot (WB) analysis of IKKγ (S31) pAb