Anti-4E-BP1 Antibody (4EB1T37T46-A5) APC BHA10600007

Eukaryotic translation initiation factor 4E-binding protein 1 (PHAS-1, EIF4EBP1, eIF4E-binding protein 1, phospho 4E-BP1) is one member of a family of translation repressor proteins encoded by the EIF4EBP gene (1). The protein directly inhibits cap-dependent translation by binding eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multi-subunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of cap-dependent mRNA translation(2). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of phospho 4E-BP1 to eIF4E, it is thought to prime phospho 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70.