S1PL-IN-31

Mfr.No.	T83910
Description	S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Demonstrating therapeutic potential, this compound, at a dosage of 2 mg/kg per day, effectively mitigates cervical and thoracic lymphocyte infiltration and neuromuscular weakness in rats suffering from experimental autoimmune encephalomyelitis (EAE), a condition triggered by the MOG29-152 peptide from myelin oligodendrocyte glycoprotein. Additionally, it significantly decreases the total lymphocyte count, including reductions in subsets of CD4+ T cells, CD8+ T cells, and B cells. At a higher dosage of 100 mg/kg, S1PL-IN-31 elevates S1P levels within the heart and lymph nodes, while doses of 3 and 10 mg/kg per day notably lower heart rates in female rats, showcasing its multifaceted biological impacts and potential for clinical application.
Molecular Formula	C26H23ClN6
Signaling Pathways	Others
Smiles	C(CH)(N(C1=CC=C(C=N1)CN)CC2)CN2C3=NN=C(C4=C3C=C(C=C4)Cl)CC5=CC=CC=C5
Cas Number	1538574-95-6
Molecular Weight	454.95
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20445517	T83910	1 mg	$173	Add to Cart
BHB20445517	T83910	5 mg	$648	Add to Cart
BHB20445517	T83910	10 mg	$1120	Add to Cart