J-104132

Mfr.No.	T27647
Description	J-104132 is a potetn and selective endothelin A/B receptor antagonist (Ki: cloned human ETA = 0.034 nM; cloned human ETB = 0.104 nM) . In vitro, J-104132 is a potent antagonist of ET-1-induced accumulation of (3H)inositol phosphates in Chinese hamster ovary cells stably expressing cloned human ETA receptors (IC50 = 0.059 nM). Pretreatment with J-104132 prevents the lethal response to ET-1 when administered i.v. (ED50 = 0.045 mg/kg) or p.o. in fed animals (ED50 = 0.35 mg/kg).
Alternative Names	J104132
Molecular Formula	C31H33NO7
Signaling Pathways	Others
Smiles	C(O)(=O)(CH)1(CH)(C=2C((CH)1C=3C=C4C(=CC3)OCO4)=CC=C(CCCC)N2)C5=C(C(CH)(C(O)=O)C)C=C(OC)C=C5
Cas Number	198279-45-7
Molecular Weight	531.6
Target	Others

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SKU	Supplier No.	Size	Your price
BHB20417514	T27647	25 mg	$4370	Add to Cart
BHB20417514	T27647	50 mg	$5780	Add to Cart
BHB20417514	T27647	100 mg	$8200	Add to Cart