ADL 08-0011 HCl

Mfr.No.	T70267
Description	ADL 08-0011 is an active metabolite of the u-opioid receptor antagonist alvimopan. It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a u-opioid receptor antagonist (Ki = 0.25 nM). It is selective for u-opioid receptors over kappa- and delta-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.
Molecular Formula	C23H30ClNO3
Signaling Pathways	Others
Smiles	Cl.C(CH)1CN(C(CH)(Cc2ccccc2)C(O)=O)CC(C)1(C)c1cccc(O)c1
Cas Number	170098-43-8
Molecular Weight	403.947
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20437543	T70267	10 mg	$2700		Add to Cart