6-Aminophenanthridine

Mfr.No.	T38187
Description	6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the alpha2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 uM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive wing position defects in a Drosophila model of oculopharyngeal muscular dystrophy (OPMD) when larvae are raised on medium containing doses ranging from 300 to 400 uM and in adults following dietary administration of 1-3 mM doses. 6-Aminophenanthridine also reduces muscle degeneration and decreases the number of nuclear inclusions in thoracic muscle in a Drosophila model of OPMD.
Molecular Formula	C13H10N2
Signaling Pathways	Others
Smiles	NC1=C2C(=C3C(=N1)C=CC=C3)C=CC=C2
Cas Number	832-68-8
Molecular Weight	194.23
Target	Others

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SKU	Supplier No.	Size	Your price	Quantity
BHB20427172	T38187	5 mg	$273		Add to Cart