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Home / Proteins & Peptide

Recombinant Mouse PD-1/PDCD1 Protein (Fc Tag)(Active)

SKU : BHP10305528

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM041289
Description	Recombinant Mouse PD-1 is produced by our Mammalian expression system and the target gene encoding Leu25-Gln167 is expressed with a Fc tag at the C-terminus.
Alternative Names	Programmed cell death protein 1;PD-1;CD279;Pdcd1;mPD-1
Reconstitution	Please refer to the printed manual for detailed information.
Background	Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
Reactivity	Mouse
Tag	C-Fc
Formulation	Lyophilized from a 0.2 um filtered solution of 20mM Tris,150mM NaCl,pH8.0.
Host	Human Cells
Accession Number	Q02242
Endotoxin Level	< 1.0 EU per ?g as determined by the LAL method.
Bioactivity	Immobilized Human PD-L1-His(Cat: PKSH033557) at 2ug/ml(100 ul/well) can bind Mouse PD-1-Fc.
Mol Weight	43.3 kDa
Mw(kda)	43.3 kDa

Sequence Info	Leu25-Gln167

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95% as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10305528	PKSM041289	10ug	$62		Add to Cart
BHP10305528	PKSM041289	50ug	-		Add to Cart

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