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Home / Proteins & Peptide

Recombinant Mouse ICOS Ligand/ICOSL Protein (His Tag)(Active)

SKU : BHP10301546

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSM040815
Alternative Names	Icosl ; AU044799 ; B7-H2 ; B7RP-1 ; B7h ; BG071784 ; GI50 ; GL50 ; GL50-B ; ICOS-L ; KIAA0653 ; LICOS ; Ly115l ; Mkiaa0653
Antigen	ICOS Ligand / B7-H2 / ICOSLG
Background	Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
Tag	His tag
Description	A DNA sequence encoding the mouse B7-H2 (NP_056605.1) extracellular domain (Met 1-Lys 279) was fused with a polyhistidine tag at the C-terminus.
Regulatory	RUO
Host	Human Cells
Endotoxin Level	< 1.0 EU per μg of the protein as determined by the LAL method
Nature	Recombinant

Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Buffer	Lyophilized from sterile PBS, pH 7.4
Description	Please refer to the printed manual for detailed information.
Purity	> 95 % as determined by SDS-PAGE
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10301546	PKSM040815	100ug	$670		Add to Cart
BHP10301546	PKSM040815	1mg	-		Add to Cart

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