Recombinant Human T-cell immunoreceptor with Ig and ITIM domains(TIGIT),partial

Mfr.No.	CSB-EP675446HU
Description	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Alternative Names	V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, V-set and immunoglobulin domain-containing protein 9 V-set and transmembrane domain-containing protein 3
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	22-141aa
Mol Weight	29.1kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Cell membrane, Single-pass type I membrane protein
Uniprot	Q495A1, Q495A1
Database Links	HGNC:26838 OMIM:612859 KEGG:hsa:201633 STRING:9606.ENSP00000373167 UniGene:Hs.421750
Function	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
Research Area	Immunology
Tissue Specificity	Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).
Weight	29.1 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol