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Recombinant Human DNA (cytosine-5)-methyltransferase 3A(DNMT3A) ,partial

BHP10501635
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Email
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Involvement In Disease Tatton-Brown-Rahman syndrome (TBRS)
Subcellular Location Nucleus, Cytoplasm
Uniprot Q9Y6K1, Q9Y6K1
Database Links

HGNC:2978

OMIM:602769

KEGG:hsa:1788

STRING:9606.ENSP00000264709

UniGene:Hs.515840
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Protein Families Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
Research Area Epigenetics and Nuclear Signaling
Tissue Specificity Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Weight 29.9kDa
Stotage Note Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer Tris-based buffer，50% glycerol
Purity Greater than 90% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer Tris-based buffer,50% glycerol
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10501635 CSB-EP897314HU 1mg $1812
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BHP10501635 CSB-EP897314HU 100ug $419
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BHP10501635 CSB-EP897314HU 20ug $224
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