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Home / Proteins & Peptide

Recombinant Human BPI fold-containing family A member 1(BPIFA1)

SKU : BHP10503933

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-CF868269HU
Alternative Names	Lung-specific protein X ; Nasopharyngeal carcinoma-related protein ; Palate lung and nasal epithelium clone protein ; Secretory protein in upper respiratory tracts ; Short PLUNC1 ; SPLUNC1 ; Tracheal epithelium-enriched protein ; Von Ebner protein Hl
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.
Source	in vitro E.coli expression system
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Lung-specific protein X; Nasopharyngeal carcinoma-related protein; Palate lung and nasal epithelium clone protein; Secretory protein in upper respiratory tracts; Short PLUNC1; Short name: SPLUNC1; Tracheal epithelium-enriched protein; Von Ebner protein Hl
Expression Region	20-256aa
Mol Weight	40.7kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Secreted
Uniprot	Q9NP55, Q9NP55
Database Links	HGNC:15749 OMIM:607412 KEGG:hsa:51297 STRING:9606.ENSP00000346251 UniGene:Hs.211092
Function	Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. May be associated with tumor progression.
Protein Families	BPI/LBP/Plunc superfamily, Plunc family
Research Area	Cancer
Tissue Specificity	Lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium. Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues. Highest expression in the trachea and progressive decrease from proxim
Weight	42.75kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503933	CSB-CF868269HU	100ug	$1420		Add to Cart
BHP10503933	CSB-CF868269HU	20ug	$878		Add to Cart

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