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Home / Proteins & Peptide

Recombinant Human Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe(LFNG)

SKU : BHP10503786

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP839868HU
Alternative Names	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Antigen	LFNG
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning
Source	E.coli
Abbreviation	LFNG
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe EC= 2.4.1.222Alternative name(s): O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Expression Region	1-250aa
Mol Weight	55.2kDa
Nature	recombinant
Protein Description	Full Length of Isoform 2

Involvement In Disease	Spondylocostal dysostosis 3, autosomal recessive (SCDO3)
Subcellular Location	Golgi apparatus membrane, Single-pass type II membrane protein
Uniprot	Q8NES3, Q8NES3
Database Links	HGNC:6560 OMIM:602576 KEGG:hsa:3955 STRING:9606.ENSP00000222725 UniGene:Hs.159142
Function	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1
Pathway	Notch signaling pathway
Protein Families	Glycosyltransferase 31 family
Research Area	Neuroscience
Weight	55.15kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503786	CSB-EP839868HU	1mg	$2466		Add to Cart
BHP10503786	CSB-EP839868HU	100ug	$578		Add to Cart
BHP10503786	CSB-EP839868HU	20ug	$306		Add to Cart

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