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Home / Proteins & Peptide

Recombinant Human ACLY/acly/ATP citrate lyase Protein (His Tag)

SKU : BHP10302859

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031004
Alternative Names	ACL;ATPCL;CLATP
Reconstitution	Please refer to the printed manual for detailed information.
Background	ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation.
Reactivity	Human
Tag	N-His
Description	A DNA sequence encoding the human ACLY (P53396) (Met 1-Met 1101) was expressed, with a polyhistidine tag at the N-terminus.
Formulation	Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 10% gly
Host	Baculovirus-Insect Cells
Accession Number	P53396
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	123 kDa
Mw(kda)	123 kDa

Sequence Info	Met 1-Met 1101

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302859	PKSH031004	50ug	$1024		Add to Cart

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