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Home / Proteins & Peptide

Recombinant Human 11-beta-hydroxysteroid dehydrogenase type 2(HSD11B2)

SKU : BHP10502331

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP010765HU
Alternative Names	11-beta-hydroxysteroid dehydrogenase type 2 ,11-DH2 ,11-beta-HSD211-beta-hydroxysteroid dehydrogenase type II ,-HSD11 type IINAD-dependent 11-beta-hydroxysteroid dehydrogenase ,11-beta-HSDShort chain dehydrogenase/reductase family 9C member 3, 11-beta-hydroxysteroid dehydrogenase type 2 ; 11-DH2 ; 11-beta-HSD211-beta-hydroxysteroid dehydrogenase type II ; -HSD11 type IINAD-dependent 11-beta-hydroxysteroid dehydrogenase ; 11-beta-HSDShort chain dehydrogenase/reductase family 9C member 3
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Corticosteroid 11-beta-dehydrogenase isozyme 2; EC= 1.1.1.-; Alternative name(s): 11-beta-hydroxysteroid dehydrogenase type 2; Short name= 11-DH2; Short name= 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase
Expression Region	1-405aa
Mol Weight	46.1kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	Apparent mineralocorticoid excess (AME)
Subcellular Location	Microsome, Endoplasmic reticulum
Uniprot	P80365, P80365
Database Links	HGNC:5209 OMIM:218030 KEGG:hsa:3291 STRING:9606.ENSP00000316786 UniGene:Hs.1376
Function	Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Protein Families	Short-chain dehydrogenases/reductases (SDR) family
Research Area	Cancer
Tissue Specificity	Expressed in kidney, pancreas, prostate, ovary, small intestine and colon. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis (PubMed:8530071).
Weight	46.1kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502331	CSB-YP010765HU	500ug	$1298		Add to Cart
BHP10502331	CSB-YP010765HU	100ug	$470		Add to Cart
BHP10502331	CSB-YP010765HU	20ug	$250		Add to Cart

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