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Home / Proteins & Peptide

Recombinant Arabidopsis thaliana rRNA 2-O-methyltransferase fibrillarin 1(FIB1)

SKU : BHP10503880

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP861762DOA
Alternative Names	Histone-glutamine methyltransferase, SKP1-interacting partner 7, rRNA 2'-O-methyltransferase fibrillarin 1 (EC:2.1.1.-), Histone-glutamine methyltransferase ; SKP1-interacting partner 7 ; rRNA 2'-O-methyltransferase fibrillarin 1 (EC:2.1.1.-)
Antigen	MED36B
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus
Source	E.coli
Abbreviation	FIB1
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: rRNA 2'-O-methyltransferase fibrillarin 1; EC= 2.1.1.-; Alternative name(s): SKP1-interacting partner 7
Expression Region	1-308aa
Mol Weight	48.8kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus, nucleolus
Uniprot	Q9FEF8, Q9FEF8
Database Links	KEGG:ath:AT5G52470 STRING:3702.AT5G52470.1 UniGene:At.22470
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).
Protein Families	Methyltransferase superfamily, Fibrillarin family
Research Area	Others
Tissue Specificity	Ubiquitously expressed, with higher levels in roots and flowers, and lower levels in siliques.
Weight	50.18kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Mus Musculus (Mouse)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503880	CSB-EP861762DOA	1mg	$2466		Add to Cart
BHP10503880	CSB-EP861762DOA	100ug	$729		Add to Cart
BHP10503880	CSB-EP861762DOA	20ug	$388		Add to Cart

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