Human PRNP(90-230) Protein, hFc Tag

Mfr.No.	PME100728
Description	Recombinant human PRNP(90-230) protein with C-terminal human Fc tag
Background	The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of fIVe tandem octapeptide repeats. This gene is found on chromosome 20, approXimately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. AlternatIVe splicing results in multiple transcript variants. (proVIded by RefSeq, Nov 2014)
Tag	C-Human Fc tag
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Molecular Weight	The protein has a predicted molecular mass of 42.2 kDa after removal of the signal peptide. The apparent molecular mass of PRNP(90-230)-hFc is approXimately 55-70 kDa due to glycosylation.
Host	HEK293
Notes	Research use only

Purity	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Storage	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).

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SKU	Supplier No.	Size	Your price
BHP18100617	PME100728	100 ug	$340	Add to Cart
BHP18100617	PME100728	50 ug	$230	Add to Cart
BHP18100617	PME100728	10 ug	$60	Add to Cart