• Alternative Names :
• Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2), RRM2B, P53R2

• Antigen :
• RRM2B

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• Non-conjugated

• Description :
• Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)

• Involvement In Disease :
• Mitochondrial DNA depletion syndrome 8A (MTDPS8A); Mitochondrial DNA depletion syndrome 8B (MTDPS8B); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 (PEOA5)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, Nucleus

• Uniprot :
• Q7LG56

• Database Links :
• 
  

  HGNC:17296

  OMIM:604712

  KEGG:hsa:50484

  STRING:9606.ENSP00000251810

  UniGene:Hs.512592

• Function :
• Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

• Pathway :
• p53 signaling pathway

• Protein Families :
• Ribonucleoside diphosphate reductase small chain family

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity Purified

• Purity :
• Antigen Affinity Purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :