• Alternative Names :
• B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10), BCL10, CIPER CLAP

• Antigen :
• BCL10

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• Non-conjugated

• Description :
• Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human B-cell lymphoma/leukemia 10 protein (1-233AA)

• Involvement In Disease :
• Immunodeficiency 37 (IMD37); Lymphoma, mucosa-associated lymphoid type (MALTOMA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human, Mouse

• Regulatory :
• RUO

• Relevance :
• Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, perinuclear region, Membrane raft

• Uniprot :
• O95999

• Database Links :
• 
  

  HGNC:989

  OMIM:137245

  KEGG:hsa:8915

  STRING:9606.ENSP00000271015

  UniGene:Hs.193516

• Function :
• Involved in adaptive immune response

• Pathway :
• NF-kappa B signaling pathway B cell receptor signaling pathway T cell receptor signaling pathway

• Research Area :
• Cell Biology

• Tissue Specificity :
• Ubiquitous.

• Buffer :
• PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• Antigen Affinity purified

• Purity :
• Antigen Affinity purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Reference :
• • Mitochondrial levels determine variability in cell death by modulating apoptotic gene expression Mrquez-Jurado S.et al,Nat Commun,Jan 26

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunohistochemistry (IHC) Protocol :