• Alternative Names :
• Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3), RIPK3, RIP3

• Antigen :
• RIPK3

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Conjugate :
• Non-conjugated

• Description :
• Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human Receptor-interacting serine/threonine-protein kinase 3 protein (1-518AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, cytosol, Cell membrane, Mitochondrion

• Uniprot :
• Q9Y572

• Database Links :
• 
  

  HGNC:10021

  OMIM:605817

  KEGG:hsa:11035

  STRING:9606.ENSP00000216274

  UniGene:Hs.268551

• Function :
• Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes

• Pathway :
• TNF signaling pathway Necroptosis NOD-like receptor signaling pathway

• Protein Families :
• Protein kinase superfamily, TKL Ser/Thr protein kinase family

• Research Area :
• Cell Biology

• Tissue Specificity :
• Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Reference :
• • Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis Endo S.et al,Biochem Biophys Res Commun,Feb 13

• Datasheet :
• 

• ELISA Protocol :

• Western Blotting(WB) Protocol :

• Immunofluorescence (IF) Protocol :