• Alternative Names :
• m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc), DCP2, NUDT20

• Categories :
• Primary Antibodies

• Clonality :
• polyclonal

• Description :
• Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.

• Host :
• Rabbit

• Immunogen :
• Recombinant Human m7GpppN-mRNA hydrolase protein (1-385AA)

• Isotype :
• IgG

• Raised In :
• Rabbit

• Reactivity :
• Human

• Regulatory :
• RUO

• Relevance :
• Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.

• Species :
• Homo Sapiens (Human)

• Subcellular Location :
• Cytoplasm, P-body, Nucleus

• Uniprot :
• Q8IU60

• Database Links :
• 
  

  HGNC:24452

  OMIM:609844

  KEGG:hsa:167227

  STRING:9606.ENSP00000373715

  UniGene:Hs.443875

• Function :
• Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs

• Protein Families :
• Nudix hydrolase family, DCP2 subfamily

• Research Area :
• Epigenetics and Nuclear Signaling

• Tissue Specificity :
• Expressed in brain and testis. Not detected in heart (at protein level).

• Buffer :
• Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Form :
• Liquid

• Format :
• Liquid

• Purification :
• >95%, Protein G purified

• Purity :
• >95%,Protein G purified

• Storage :
• Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

• Storage Buffer :
• 
  
  Preservative: 0.03% Proclin 300
  Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

• Datasheet :
• 

• ELISA Protocol :

• Immunohistochemistry (IHC) Protocol :