Mitoxantrone-Resistant SF295 Cell Line (MX500)

Mfr.No.	T8041
Description	The human malignant glioma cell line (SF295) was selected in increasing concentrations of mitoxantrone to yield these cell lines. Cells were maintained in constant culture with mitoxantrone for 3 months before cytogenetic analysis was conducted. MX# indicates the mitoxantrone concentration that the cell line is resistant to in nmol/L. Northern blot analysis was used to confirm ABCG2 expresion in mitoxantrone selected SF295 sublines. The cell lines show increasing ABCG2 expression at the RNA level with increasing mitoxantrone concentration. These cell lines are suitable for studies investigating drug resistance in clinical oncology.
Density	Recommended split ratio 1:10
Growth Properties	Adherent
Quantity	1x10⁶ cells / 1.0 ml
Organism	Human (H. sapiens)
Markers	ABCG2
Source Organ	Brain

Shipping	Dry Ice
Storage	-180°C

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SKU	Supplier No.	Your price	Quantity
BHC10901748	T8041	-		Add to Quote